By Mark D. Rothmann,Rothmann

ISBN-10: 1584888040

ISBN-13: 9781584888048

The elevated use of non-inferiority research has been followed via a proliferation of analysis at the layout and research of non-inferiority reviews. utilizing examples from actual medical trials, Design and research of Non-Inferiority Trials brings jointly this physique of analysis and confronts the problems inquisitive about the layout of a non-inferiority trial. every one bankruptcy starts off with a non-technical advent, making the textual content simply understood by way of these with no previous wisdom of this sort of trial.

Topics lined include:

  • A number of problems with non-inferiority trials, together with a number of comparisons, lacking information, research inhabitants, using defense margins, the interior consistency of non-inferiority inference, using surrogate endpoints, trial tracking, and equivalence trials

  • Specific concerns and research equipment while the information are binary, non-stop, and time-to-event

  • The background of non-inferiority trials and the layout and behavior concerns for a non-inferiority trial

  • The energy of proof of an efficacy discovering and the way to guage the impact measurement of an energetic keep watch over therapy

A entire dialogue at the goal and concerns concerned with non-inferiority trials, Design and research of Non-inferiority Trials will support present and destiny scientists and statisticians at the optimum layout of non-inferiority trials and in assessing the standard of non-inferiority comparisons performed in practice.

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Design and Analysis of Non-Inferiority Trials (Chapman & Hall/CRC Biostatistics Series) by Mark D. Rothmann,Rothmann

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